The substantial goal is how the creative tourism in rural areas can develop through tourism activities where the tourist can develop the creative potential through active participation in the experience of learning arts, legacies, or special characteristics of the location as the destination.The implementation method explains clearly about the rese
Developing SHP2-based combination therapy for KRAS-amplified cancer
Gastroesophageal adenocarcinomas (GEAs) harbor recurrent amplification of KRAS, leading to marked overexpression of WT KRAS protein.We previously demonstrated that SHP2 phosphatase, which acts to promote KRAS and downstream MAPK pathway activation, is a target in these tumors when combined with MEK inhibition.We hypothesized that SHP2 inhibitors ma
The Nasopalatine Ducts Are Required for Proper Pheromone Signaling in Mice
The vomeronasal organ (VNO) specializes satisfyer pro penguin next generation in detection of chemosignals, mainly pheromones, which control social communication and reproduction in many mammals.These pheromones must solubilize with nasal fluids before entering the VNO, and it was suggested that they are delivered to and cleared from the VNO by act
Considerations for de-escalating universal masking in healthcare centers
Three years after the beginning of the COVID-19 pandemic, better knowledge on the transmission of respiratory viral infections (RVI) including the contribution of asymptomatic infections encouraged most healthcare centers to implement universal masking.The evolution of the SARS-CoV-2 epidemiology and improved immunization of the population call for
Susceptibility assessment of landslides: A comparison of two GIS-based methods in the region of Al Hoceima (Eastern Rif, Morocco).
The evaluation of the degree of susceptibility to landslides has become a major concern in mountainous areas, it is a key component of manager policies efforts in disaster prevention, mitigate risk and manage the consequences.The region of Al Hoceima is one of most mountain regions in Morocco, and is highly exposed landslides events.For this reason